Patrik Brundin Laboratory

Selected Publications

Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P. In press. Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta Neuropathol.    Article

Thirtamara-Rajamani K, Li P, Escobar Galvis ML, Labrie V, Brundin P, Brundin L. 2017. Is the enzyme ACMSD a novel therapeutic target in Parkinson’s disease? J Parkinson Dis 7(4):577–587.     Article

Rey NL, Wesson DW, Brundin P. In press. The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases. Neurobiol Dis.   Article

Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P. 2016. Mitochondrial pyruvate carrier regulates autophagy, inflammation and neurodegeneration in experimental models of Parkinson’s disease. Sci Transl Med 8(368):368ra174     Article

Coetzee SG, Pierce S, Brundin P, Brundin L, Hazelett DJ, Coetzee GA. In press. Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson’s disease etiology. Sci Rep.       Article

Brundin P, Wyse R. 2015. Parkinson disease: laying the foundations for disease-modifying therapies in PD. Nat Rev Neurol 11(10):553–555  
PubMed         Article

George S, Brundin P. 2015. Immunotherapy in Parkinson’s disease: micromanaging alpha-synuclein aggregation. J Parkinsons Dis 5(3):413–424.     PubMed

Grey M, Dunning CJ, Gaspar R, Grey C, Brundin P, Sparr E, Linse S. 2015. Acceleration of α-synuclein aggregation by exosomes. J Biol Chem 290(5):2969–2982.  Article

Nordström U, Beauvais G, Ghosh A, Sasidharan BCP, Lundblad M, Fuchs J, Joshi RL, Lipton JW, Roholt A, Medicetty S, Feinstein TN, Steiner JA, Galvis MLE, Prochiantz A, Brundin P. 2015. Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson’s disease. Neurobiol Dis 73(1):70–82.       PubMed

Reyes JF, Rey NL, Bousset L, Melki R, Brundin P, Angot E. 2014. Alpha-synuclein transfers from neurons to oligodendrocytes. Glia 62(3):387–398.        Article

Rey NL, Petit GH, Bousset L, Melki R, Brundin P. 2013. Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol 126(4):555–573.     PubMed

Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL, Joseph B. 2011. Caspase signalling controls microglia activation and neurotoxicity. Nature 472(7343):319–324.               PubMed         Article

Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY, Brundin P. 2011. Alpha-synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 121(2): 715–725.        PubMed         Article

Angot E, Steiner JA, Hansen C, Li JY, Brundin P. 2010. Are synucleinopathies prion-like disorders?. Lancet Neurol 9(11):1128–1138.         PubMed          Article

Brundin P, Melki R, Kopito R. 2010. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 11(4):301–307.         PubMed          Article 

Brundin P, Li JY, Holton JL, Lindvall O, Revesz T. 2008. Research in motion: the enigma of Parkinson’s disease pathology spread. Nat Rev Neurosci 9(10):741–745.         PubMed         Article 

Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Björklund A, Widner H, Revesz T, Lindvall O, Brundin P. 2008. Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation. Nat Med 14(5):501–503.   PubMed        Article  

Ciechanover A, Brundin P. 2003. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 40(2):427–446.   PubMed         Article 

Lotharius J, Brundin P. 2002. Pathogenesis of Parkinson’s disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci 3(12):932–942.        PubMed         Article  

Brundin P, Pogarell O, Hagell P, Piccini P, Widner H, Schrag A, Kupsch A, Crabb L, Odin P, Gustavii B, Björklund A, Brooks DJ, Marsden CD, Oertel WH, Quinn NP, Rehncrona S, Lindvall O. 2000. Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson’s disease. Brain 123(Pt 7):1380–1390.       PubMed          Article  

Hagell P, Schrag A, Piccini P, Jahanshahi M, Brown R, Rehncrona S, Widner H, Brundin P, Rothwell JC, Odin P, Wenning GK, Morrish P, Gustavii B, Björklund A, Brooks DJ, Marsden CD, Quinn NP, Lindvall O. 1999. Sequential bilateral transplantation in Parkinson’s disease: effects of the second graft. Brain 122(Pt 6):1121–1132.              PubMed         Article  

Hansson O, Petersén A, Leist M, Nicotera P, Castilho RF, Brundin P. 1999. Transgenic mice expressing a Huntington’s disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity. Proc Natl Acad Sci U S A 96(15):8727–8732.    PubMed          Article 

Schierle GS, Hansson O, Leist M, Nicotera P, Widner H, Brundin P. 1999. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nat Med 5(1):97–100.           PubMed          Article  

Brundin P, Björklund A. 1998. Survival of expanded dopaminergic precursors is critical for clinical trials. Nat Neurosci 1(7):537.       PubMed         Article  

Nakao N, Frodl EM, Widner H, Carlson E, Eggerding FA, Epstein CJ, Brundin P. 1995. Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson’s disease. Nat Med 1(3):226–231.      PubMed  

Nakao N, Frodl EM, Duan WM, Widner H, Brundin P. 1994. Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Proc Natl Acad Sci U S A 91(26):12408–12412.              PubMed          Article  

Horellou P, Brundin P, Kalén P, Mallet J, Björklund A. 1990. In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum. Neuron 5(4):393–402.    PubMed               Article

Lindvall O, Brundin P, Widner H, Rehncrona S, Gustavii B, Frackowiak R, Leenders KL, Sawle G, Rothwell JC, Marsden CD, et al. 1990. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson’s disease. Science 247(4942):574–577.           PubMed         Article  

Wictorin K, Brundin P, Gustavii B, Lindvall O, Björklund A. 1990. Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts. Nature 347(6293):556–558.              PubMed               Article